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Alex Cherutic Kipnyargis Publications

 

  • Kiplimo D., Mugweru J., Kituyi S., Kipnyargis A., Mwirichia R. (2019). Diversity of esterase and lipase producing haloalkaliphilic bacteria from Lake Magadi in Kenya. J Basic Microbiol. 2019;1–12. DOI: 10.1002/jobm.201900353
  • Kipnyargis, A.C., Khamis, F.M. Kenya, E. U., Ekesi, S. & Fiaboe, K.K.M. (2018) Genetic diversity of aphid (Hemiptera: Aphididae) species attacking amaranth and nightshades in different agro-ecological zones of Kenya and Tanzania African Entomology 26(2): 407–421 (2018) DOI: https://doi.org/10.4001/003.026.0407 ISSN 1021-3589 [Print]; 2224-8854 [Online]

Presentation of Papers at Academic and Professional Conferences

  • Kipnyargis, A. C., Khamis, F. M., Kenya, E. U. and Fiaboe, K. M. (2017). Genetic diversity of aphid (Hemiptera: Aphididae) species attacking amaranth and nightshades in different agro-ecological zones of Kenya and Tanzania. Presented during the ICIPE international Science Week (2015)

Mr. Joshua Kiilu Muli Publications

  1. Muli J.K., J O. Neondo, P. K. Kamau and N.L.M. Budambula (2020).  Genetic diversity and use of African indigenous vegetables especially slender leaf.  International Journal of Vegetable Science  https://doi.org/10.1080/19315260.2020.1829768
  2. Mwakha, F. A., Gichimu, B.M., Neondo, J.O., Kamau, P.K, Odari, E. O., Muli, J. K., Budambula, N.L.M (2020). Agro-Morphological Characterization of Kenyan Slender Leaf (Crotalaria brevidens and C. ochroleuca) Accessions. Hindawi, International Journal of Agronomy Volume 2020, Article ID 2710907, 10 pages https://doi.org/10.1155/2020/2710907
  3. Muli J. K., N. Budambula, C. Mweu and S. E. Anami (2018). Drought Response in Selected Tropical Inbred Maize Lines and Relative Expression of PARP2 Gene under Limited Water Conditions. Plant 6:8-15. doi: 10.11648/j.plant.20180601.12
  4. Naaty, B., Mbithe, C. M., Nyende, A. B., Njenga, P., Muli J.K. (2017). In Vitro Regeneration via Somatic Embryogenesis of Schizozygia coffeoides. balli (Mpelepele). American Journal of Plant Biology 2(2): 66-72.
  5. Muli J.K., N. L. M. Budambula, C. Mweu, M. C. Imbo and S. E. Anami (2016).  Genetic Improvement of African Maize towards Drought Tolerance: A Review. Advances in Life Science and Technology 48: 1-9
  6. Imbo M.C., N. L. M. Budambula, C.M. Mweu, Muli J.K. and S. E. Anami (2016). Genetic Transformation of Sweet Potato for Improved Tolerance to Stress: A Review.  Advances in Life Science and Technology 49:67-76
  7. Muli J.K., N. L. M. Budambula, C. Mweu, and S. E. Anami.  Yeast Extract Peptone based Co-cultivation Media Promotes Transient GUS Expression in Tropical Maize Genotypes.  Asian journal of crop science 9(3):71-81.

Dr Sarah Naulikha Kituyi Publications

  1. Beckley, S.J.; Hunter, M.C.; Kituyi, S.N.; Wingate, I.; Chakraborty, A.; Schwarz, K.; Makhubu, M.P.; Rousseau, R.P.; Ruck, D.K.; de la Mare, J.-A.; Blatch, G.L.; Edkins, A.L. (2020) STIP1/HOP Regulates the Actin Cytoskeleton through Interactions with Actin and Changes in Actin-Binding Proteins Cofilin and Profilin. Int. J. Mol. Sci. 2020, 21, 3152.
  2. Kiplimo D, Mugweru J, Kituyi S, Kipnyargis A, Mwirichia R. Diversity of esterase and lipase producing haloalkaliphilic bacteria from Lake Magadi in Kenya. J Basic Microbiol. 2019;1–12. https://doi.org/10.1002/jobm.201900353
  3. Kituyi, S.N., Edkins. L.K. (2018) Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin. ISSN 0006-291X, https://doi.org/10.1016/j.bbrc.2018.11.073.
  4. Kituyi, S. N et al ., How well do malaria tests correlate with disease severity? Comparison of parasite density in children with mild and severe malaria.Malaria World Journal 2014 5:7 http://www.malariaworld.org/sites/default/files/mwjournal/article/MWJ2014_5_7
  5. Kituyi, S. N & Adrienne LE .,Hop depletion disrupts nuclear structure by depletion of emerin. Submitted for publication to the BBA- Molecular cell research Journal BBAMCR-17-443.
  6. Clinton G.L. Veale, Weiyang Chenc, Sushil Chaudharyc, Kituyi, S. N , Michelle Isaacs, Heinrich Hoppe, Adrienne L. Edkins, Sandra Combrinck Bewketu Mehari NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum.Phytochemistry Letters 23 (2018) 189–193
  7. ​Wingate I, Adrienne LE, Kituyi SN & De La Mere JA., Identification of​ Novel Roles of Hop via Proteomic Analysis. Manuscript in preparation for Submission to the Journal of Cell Stress by April 2018
  8. ​Beckley SJ, Kituyi, S. N , Blatch G & Adrienne LE, The Role of Stress Inducible Protein 1 in the Regulation of Actin Dynamics. Manuscript in preparation for Submission to the BBA-Molecular Cell Research Journal by May 2018

Conferences Attended

•    Keystone eSymposia meeting on Vaccinology in the Age of Pandemics: Strategies Against COVID-19 & Other Global Threats on June 15-16, 2020.
•    The 8th international congress on the HSP90 chaperone in Seeon-Bayern
Germany-2016
•     The 25th South African Society for Biochemistry and Microbiology (SASMB) conference in East London- 2016
•     The 6th MIM Pan-African Conference on Malaria- 2013-Durban
•    The KEMRI Annual Scientific and Health Conference (KASH-2014)- Nairobi
Professional Membership
•    The South African Society for Biochemistry and Microbiology (SASMB) 2016 to Date
•    The African Society for Laboratory Medicine-2014 to date
Research Collaborations
•    The Biomedical Biotechnology Research Unit (Biobru)-Rhodes University South Africa
•    The US Army Medical Research Unit-Basic Science Laboratory-USAMRD-KEMRI
•    The South Eastern Kenya University-SeKu

 Dr. Julius N. Mugweru Publications

  1. Makafe, G. G., Hussain, M., Surineni, G., Tan, Y., Wong, N. K., Julius, M., Liu, L.,Gift, C., Jiang, H., Tang, Y., Liu, J., Tan, S., Yu, Z., Liu, Z., Lu, Z., Fang, C., Zhou, Y., Zhang, J., Zhu, Q., Liu, J & Zhang, T. (2019). Quinoline Derivatives Kill Mycobacterium tuberculosis by Activating Glutamate Kinase. Cell chemical biology, 26(8), 1187-1194.  https://doi.org/10.1016/j.chembiol.2019.05.003
  2. Liu Y, Tan Y, Islam MM, Cao Y, Lu X, Zeng S, Hameed HMA, Zhou P, Cai X, Wang S, Mugweru JN, Zhang G, Yin H, Liu J, Nuermberger E, Zhang T. 2020. Assessment of clofazimine and TB47 combination activity against Mycobacterium abscessus using a bioluminescent approach. Antimicrob Agents Chemother 64:e01881-19. https://doi.org/10.1128/AAC.01881-19.
  3. Kiplimo D, Mugweru J, Kituyi S, Kipnyargis A, Mwirichia R. Diversity of esterase and lipase producing haloalkaliphilic bacteria from Lake Magadi in Kenya. J Basic Microbiol. 2019;1–12. https://doi.org/10.1002/jobm.201900353
  4. Chhotaray C., Y. Tan, J. Mugweru, M. M. Islam, H.M. A. Hameed, S. Wang, Z. Lu, C. Wang, X. Li, S. Tan, J. Liu, T. Zhang (2018).  Advances in the development of molecular genetic tools for Mycobacterium tuberculosis. Journal of Genetics and Genomics 45: 281-297.
  5. Mugweru J., J Liu, G.Makafe, G. Chiwala, B. Wang, C.Wang, X. Li, Y. Tan, W. W. Yew, S. Tan and T. Zhang (2018).  Mutation EthA W21R confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv. Infection and Drug Resistance 11: 891–894.
  6. Mugweru, J., Makafe, G., Cao, Y., Zhang, Y., Wang, B., Huang, S., ... & Liu, J. (2017). A Cassette Containing Thiostrepton, Gentamicin Resistance Genes, and dif sequences Is Effective in Construction of Recombinant Mycobacteria. Frontiers in microbiology, 8 (468). https://doi.org/10.3389/fmicb.2017.00468
  7. Njire, M., Wang, N, Wang, B, Tan Y., Cai, X., Liu, Y., Mugweru, J., et al. (2017) "Pyrazinoic acid inhibits a bifunctional enzyme in Mycobacterium tuberculosis." Antimicrobial agents and chemotherapy 61(7) (e00070-17. https://doi.org/10.1128/AAC.00070-17
  8. Islam, M. M., Hameed, H. A., Mugweru, J., Chhotaray, C., Wang, C., Tan, Y., ... & Yew, W. W. (2017). Drug resistance mechanisms and novel drug targets for tuberculosis therapy. Journal of Genetics and Genomics, 44(1), 21-37 http://dx.doi.org/10.1016/j.jgg.2016.10.002
  9. Makafe, G. G., Cao, Y., Tan, Y., Mugweru J., Liu, Z., Wang, C., & Pang, W. (2016). Role of the Cys154Arg substitution in ribosomal protein L3 in oxazolidinone resistance in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 60(5), 3202-3206 doi:10.1128/AAC.00152-16
  10. Njire, M., Tan, Y., Mugweru, J., Wang, C., Guo, J., Yew, W., & Zhang, T. (2016). Pyrazinamide resistance in Mycobacterium tuberculosis: Review and update. Advances in medical sciences, 61(1), 63-71. http://dx.doi.org/10.1016/j.advms.2015.09.007
  11. Tan, S., Rao, Y., Guo, J., Tan, Y., Cai, X., Kuang, H., Li, Y., Liu, W., Mugweru, J., Wang, B. and Cao, Y., (2016) The influence of pyrazinamide mono-resistance on treatment outcomes in tuberculosis patients from Southern China. Journal of Tuberculosis Research, 4(01), 9. http://dx.doi.org/10.4236/jtr.2016.41002
  12. Ouma, S. O., Mugweru, J., Ngamau, C. N., & Matiru, V. N. (2015). Evaluation of nitrogen fixation ability of endophytic bacteria in Kenyan bananas (Musa Spp.) using biochemical and molecular techniques. The International Journal of Science & Technology  2 (13)
  13. Liu, T., Wang, B., Guo, J., Zhou, Y., Julius, M., Njire, M., ... & Xu, Y. (2015). Role of folP1 and folP2 genes in the action of sulfamethoxazole and trimethoprim against mycobacteria. J. Microbiol. Biotechnol, 25(9), 1559-1567.http://dx.doi.org/10.4014/jmb.1503.03053
  14. Gechemba, O. R., Budambula N.L.M, Makonde, H.M, Mugweru J, and Matiru V.N. (2015) "Potentially beneficial rhizobacteria associated with banana plants in Juja, Kenya." Journal of Biodiversity and Environmental Sciences 7, (2) 181-188. ISSN: 2220-6663 (Print) 2222-3045 (Online)
  15. Mugweru, J., Ng'ang'a, Z. W., Waihenya, R., Kimani, F., Matiru, V., & Muregi, F. W. (2013). Cytokine levels associated with experimental malaria pathology during Plasmodium berghei ANKA infection in a mouse model. Journal of Clinical Immunology and Immunopathology Research 5(1), 1-8, DOI 10.5897/AJPP2012.0058

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Department of Biological Sciences